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The Role of Amino Acids in Advanced Cosmetic Science

The Building Blocks of Skin Vitality

Amino acids are the fundamental building blocks of proteins, including collagen, elastin, and keratin—key structural components that contribute to the appearance and integrity of healthy-looking skin. As skin is exposed to intrinsic aging and environmental stressors, these structural proteins naturally change over time, making amino acids an important focus of cosmetic science and skin biology.

Scientific literature has shown that amino acids play essential roles in maintaining skin structure and function. They contribute to the skin’s natural moisture balance, support the integrity of the skin barrier, and serve as building blocks for proteins involved in normal skin physiology. Amino acids are also recognized for their role in supporting the skin’s natural renewal processes and maintaining a balanced skin microenvironment.

At Kimera Labs, amino acids are thoughtfully incorporated into advanced cosmetic formulations to complement our MSC-derived exosome technology and support healthy-looking, hydrated, and resilient skin.

Solano F. Metabolism and Functions of Amino Acids in the Skin. Adv Exp Med Biol. 2020;1265:187-199. doi: 10.1007/978-3-030-45328-2_11. PMID: 32761577.

Amino Acid Summaries and Studies

  1. Park, J.I., et al., Oral Administration of Glycine and Leucine Dipeptides Improves Skin Hydration and Elasticity in UVB-Irradiated Hairless Mice. Biomol Ther (Seoul), 2017. 25(5): p. 528-534.
  2. Karna, E., et al., Proline-dependent regulation of collagen metabolism. Cell Mol Life Sci, 2020. 77(10): p. 1911-1918.
  3. Yamauchi, M., M. Terajima, and M. Shiiba, Lysine Hydroxylation and Cross-Linking of Collagen. Methods Mol Biol, 2019. 1934: p. 309-324.
  4. Wu, G., et al., Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Adv Exp Med Biol, 2021. 1332: p. 167-187.
  5. Karimpour, M., et al., Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats. Iranian Journal of Basic Medical Sciences, 2018. 21(8): p. 842-847.
  6. Janeczek, M., et al., The Potential Uses of N-acetylcysteine in Dermatology: A Review. J Clin Aesthet Dermatol, 2019. 12(5): p. 20-26.
  7. Lin, C.H., et al., In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species. Acta Pharmacol Sin, 2011. 32(9): p. 1181-90.
  8. Ahsan, H., Immunopharmacology and immunopathology of peptides and proteins in personal products. J Immunoassay Immunochem, 2019. 40(4): p. 439-447.
  9. Gu, C., et al., Isoleucine Plays an Important Role for Maintaining Immune Function. Curr Protein Pept Sci, 2019. 20(7): p. 644-651.
  10. Pawar, K., et al., Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin. J Pharm Sci, 2017. 106(7): p. 1814-1820.
  11. di Lorenzo, R., et al., Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential. Molecules, 2021. 26(21).
  12. Friedman, M., Analysis, Nutrition, and Health Benefits of Tryptophan. Int J Tryptophan Res, 2018. 11: p. 1178646918802282.
  13. Rzepka, Z., et al., From tyrosine to melanin: Signaling pathways and factors regulating melanogenesis. Postepy Hig Med Dosw (Online), 2016. 70(0): p. 695-708.
  14. Mavon, A., Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proof. Int J Cosmet Sci, 2015. 37 Suppl 1: p. 1-2.
  15. Moro, J., et al., Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species. Nutrients, 2020. 12(5).
  16. Jara, C.P., et al., Glutamic acid promotes hair growth in mice. Scientific Reports, 2021. 11(1): p. 15453.
  17. Kim, H., et al., Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid. Korean J Physiol Pharmacol, 2015. 19(6): p. 543-7.
  18. Jiravanichanun, N., et al., Threonine in Collagen Triple-helical Structure. Polymer Journal, 2006. 38(4): p. 400-403.
  19. Lomelino, C.L., et al., Asparagine synthetase: Function, structure, and role in disease. J Biol Chem, 2017. 292(49): p. 19952-19958.